- 1 - Complement in Renal Transplant Rejection
نویسنده
چکیده
The complement system plays multiple pathogenetic roles in rejection of renal allografts and one of the components, C4d, is an important diagnostic marker of antibody mediated rejection (1, 2). Complement proteins (e.g., C3) arose as an ancient, innate defense system in invertebrates that preceded the adaptive immune system in phylogeny. It is not surprising that during evolution these complement proteins and their receptors were incorporated into both the antibody and T cell mediated responses. C4 first evolved in conjunction with immunoglobulin. The Belgian microbiologist Jules Bordet (Nobel Prize 1919) discovered and defined complement as the factor(s) in fresh normal serum necessary for lysis of antibody coated red cells. The present discussion focusses on four topics: Ischemia/reperfusion injury, T cell mediated rejection, antibody mediated rejection and accommodation.
منابع مشابه
Association between Amylase Excretion Fraction and Acute Renal Transplant Rejection in Pediatrics
Background and Objectives: Serum amylase increases and its excretion fraction decreases in patients with renal failure. Excretion fraction can be used as a diagnostic way in individuals with acute renal transplant rejection. In this study, the association between amylase excretion fraction and acute renal transplant rejection, was investigated in pediatrics. Methods: in this case - control s...
متن کاملComplement 5a receptor inhibition improves renal allograft survival.
Complement activation plays a key role in mediating apoptosis, inflammation, and transplant rejection. In this study, the role of the complement 5a receptor (C5aR) was examined in human renal allografts and in an allogenic mouse model of renal transplant rejection. In human kidney transplants with acute rejection, C5aR expression was increased in renal tissue and in cells infiltrating the tubul...
متن کاملPrediction of Rejection in Renal Transplantation by Immune Parameters
Background: Monitoring of phenotypic characteristics of T-lymphocytes in peripheral blood is commonly performed to give the clinical parameters in the management of kidney transplant recipients. Objective: To predict rejection in renal transplantation by immune parameters. Methods: 16 non-diabetic kidney transplant candidates (4 females and 12 males, age = 20-65 yr, first time transplant) wer...
متن کاملRejection Rate in Kidney Transplant Recipients in Kermanshah, Iran: 1989-2016
Background and purpose: Kidney transplant is a major form of renal replacement therapy in many patients at advanced stages of the disease. Transplant rejection is a major complication following kidney transplant that could be reversible or irreversible. The present study was done to investigate the incidence of irreversible kidney transplant rejection. Materials and methods: A retrospective co...
متن کاملBK Viremia among Iranian Renal Transplant Candidates
Background: Primary infection with BK virus (BKV) is occurred during childhood and usually asymptomatic, but after initial infection, BKV may persist lifelong in the kidney and genitourinary tract. Reactivation may occur in individuals with compromised immunity such as renal transplant recipients. Due to the role of BKV in BK virus-associated nephropathy (BKVAN) and po...
متن کاملThe Sources of Stress in Renal Transplant Patients
Introduction Renal transplant is the best treatment of choice for patients with end-stage renal disease (1). Annually, about 17000 patients receive deceased or living donor transplants, which help them promote health and self-efficacy (1-2). However, despite advances in transplant technology, patients face a number of post-operative challenges, which might lead to stress in patients, includin...
متن کامل